Risk Factors Associated with HIV Transmission in Occupational Exposures

Last updated April 21, 2015
Case Authors: 
Christopher B. Behrens, MD
Clinical Associate Professor
Department sof Global Health and Medicine
University of Washington School of Medicine 
David H. Spach, MD's picture
David H. Spach, MD
Professor of Medicine
Division of Infectious Diseases
Clinical Director, Mountain West AIDS Education and Training Center
University of Washington School of Medicine
Learning Objectives: 
  1. State the approximate risk of a health care worker acquiring HIV with a needlestick injury if the health care worker does not take postexposure prophylaxis.
  2. Summarize the risk factors associated with an increased risk of HIV transmission with a needlestick injury.

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  1. U.S. Public Health Service. Updated U.S. Public Health Service Guidelines for the Management of Occupational Exposures to HBV, HCV, and HIV and Recommendations for Postexposure Prophylaxis. MMWR Recomm Rep. 2001;50:1-52.
  2. Bell DM. Occupational risk of human immunodeficiency virus infection in healthcare workers: an overview. Am J Med. 1997;102:9-15.
  3. Henderson DK. Management of needlestick injuries: a house officer who has a needlestick. JAMA. 2011;307:75-84.
  4. Kuhar DT, Henderson DK, Struble KA, et al. Updated US Public Health Service guidelines for the management of occupational exposures to human immunodeficiency virus and recommendations for postexposure prophylaxis. Infect Control Hosp Epidemiol. 2013;34:875-92.
  5. Centers for Disease Control and Prevention. HIV/AIDS Surveillance Report. Atlanta, GA: Department of Health and Human Services, CDC. 2000:24. (vol 12, no. 1).
  6. Gerberding JL. Clinical practice. Occupational exposure to HIV in health care settings. N Engl J Med. 2003;348:826-33.
  7. Borba Brum MC, Dantas Filho FF, Yates ZB, Verçoza Viana MC, Martin Chaves EB, Trindade DM. HIV seroconversion in a health care worker who underwent postexposure prophylaxis following needlestick injury. Am J Infect Control. 2012;41:471-2.
  8. Panlilio AL, Orelien JG, Srivastava PU, Jagger J, Cohn RD, Cardo DM. Estimate of the annual number of percutaneous injuries among hospital-based healthcare workers in the United States, 1997-1998. Infect Control Hosp Epidemiol. 2004;25:556-62.
  9. Cardo DM, Culver DH, Ciesielski CA, et al. A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group. N Engl J Med. 1997;337:1485-90.
  10. Bennett NT, Howard RJ. Quantity of blood inoculated in a needlestick injury from suture needles. J Am Coll Surg. 1994;178:107-10.
  11. Mast ST, Woolwine JD, Gerberding JL. Efficacy of gloves in reducing blood volumes transferred during simulated needlestick injury. J Infect Dis. 1993;168:1589-92.
  12. Resnick L, Veren K, Salahuddin SZ, Tondreau S, Markham PD. Stability and inactivation of HTLV-III/LAV under clinical and laboratory environments. JAMA. 1986;255:1887-91.
  13. Heimer R, Abdala N. Viability of HIV-1 in syringes: implications for interventions among injection drug users. AIDS Read. 2000;10:410-7.
  14. Panlilio AL, Cardo DM, Grohskopf LA, Heneine W, Ross CS. Updated U.S. Public Health Service guidelines for the management of occupational exposures to HIV and recommendations for postexposure prophylaxis. MMWR Recomm Rep. 2005 Sep 30;54:1-17.