Molluscum Contagiosum

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Last updated February 23, 2015
Case Authors: 
David H. Spach, MD's picture
Real name: 
David H. Spach, MD
Professor of Medicine
Division of Infectious Diseases
Clinical Director, Mountain West AIDS Education and Training Center
University of Washington School of Medicine
Disclosures: 
None
Learning Objectives: 
  1. Describe key clinical features of molluscum contagiosum in HIV-infected persons with advanced immune suppression.
  2. List 3 or more treatments for molluscum contagiosum in HIV-infected patients.

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References
  1. Smith KJ, Yeager J, Skelton H. Molluscum contagiosum: its clinical, histopathologic, and immunohistochemical spectrum. Int J Dermatol. 1999;38:664-72.
  2. Vera-Sempere FJ, Rubio L, Massmanian A. Counts and areas of S-100-positive epidermal dendritic cells in atypical molluscum contagiosum affecting HIV+ patients. Histol Histopathol. 2001;16:45-51.
  3. Strauss RM, Doyle EL, Mohsen AH, Green ST. Successful treatment of molluscum contagiosum with topical imiquimod in a severely immunocompromised HIV-positive patient. Int J STD AIDS. 2001;12:264-6.
  4. Schwartz JJ, Myskowski PL. Molluscum contagiosum in patients with human immunodeficiency virus infection. A review of twenty-seven patients. J Am Acad Dermatol. 1992;27:583-8.
  5. Muñoz-Pérez MA, Rodriguez-Pichardo A, Camacho F, Colmenero MA. Dermatological findings correlated with CD4 lymphocyte counts in a prospective 3 year study of 1161 patients with human immunodeficiency virus disease predominantly acquired through intravenous drug abuse. Br J Dermatol. 1998;139:33-9.
  6. Buckley R, Smith K. Topical imiquimod therapy for chronic giant molluscum contagiosum in a patient with advanced human immunodeficiency virus 1 disease. Arch Dermatol. 1999;135:1167-9.
  7. Cunningham ET Jr, Margolis TP. Ocular manifestations of HIV infection. N Engl J Med. 1998;339:236-44.
  8. Pérez-Blázquez E, Villafruela I, Madero S. Eyelid molluscum contagiosum in patients with human immunodeficiency virus infection. Orbit. 1999;18:75-81.
  9. Petersen CS, Gerstoft J. Molluscum contagiosum in HIV-infected patients. Dermatology. 1992;184:19-21.
  10. Baxter KF, Highet AS. Topical cidofovir and cryotherapy--combination treatment for recalcitrant molluscum contagiosum in a patient with HIV infection. J Eur Acad Dermatol Venereol. 2004;18:230-1.
  11. Cotell SL, Roholt NS. Images in clinical medicine. Molluscum contagiosum in a patient with the acquired immunodeficiency syndrome. N Engl J Med. 1998;338:888.
  12. Picon L, Vaillant L, Duong T, et al. Cutaneous cryptococcosis resembling molluscum contagiosum: a first manifestation of AIDS. Acta Derm Venereol. 1989;69:365-7.
  13. Manchanda Y, Sethuraman G, Paderwani PP, Singh M, Singh MK. Molluscum contagiosum presenting as penile horn in an HIV positive patient. Sex Transm Infect. 2005;81:183-4.
  14. Hurni MA, Böhlen L, Furrer H, Braathen LR. Complete regression of giant molluscum contagiosum lesions in an HIV-infected patient following combined antiretroviral therapy with saquinavir, zidovudine and lamivudine. AIDS. 1997;11:1784-5.
  15. Calista D, Boschini A, Landi G. Resolution of disseminated molluscum contagiosum with Highly Active Anti-Retroviral Therapy (HAART) in patients with AIDS. Eur J Dermatol. 1999;9:211-3.
  16. Cattelan AM, Sasset L, Corti L, Stiffan S, Meneghetti F, Cadrobbi P. A complete remission of recalcitrant molluscum contagiosum in an AIDS patient following highly active antiretroviral therapy (HAART) J Infect. 1999;38:58-60.
  17. Zancanaro PC, McGirt LY, Mamelak AJ, Nguyen RH, Martins CR. Cutaneous manifestations of HIV in the era of highly active antiretroviral therapy: an institutional urban clinic experience. J Am Acad Dermatol. 2006;54:581-8.
  18. Pereira B, Fernandes C, Nachiambo E, Catarino MC, Rodrigues A, Cardoso J. Exuberant molluscum contagiosum as a manifestation of the immune reconstitution inflammatory syndrome. Dermatol Online J. 2007;13:6.
  19. Sadick N, Sorhaindo L. A comparative split-face study of cryosurgery and trichloroacetic acid 100% peels in the treatment of HIV-associated disseminated facial molluscum contagiosum. Cutis. 2009;83:299-302.
  20. Brown CW Jr, O'Donoghue M, Moore J, Tharp M. Recalcitrant molluscum contagiosum in an HIV-afflicted male treated successfully with topical imiquimod. Cutis. 2000;65:363-6.
  21. Calista D. Topical cidofovir for severe cutaneous human papillomavirus and molluscum contagiosum infections in patients with HIV/AIDS. A pilot study. J Eur Acad Dermatol Venereol. 2000;14:484-8.
  22. Meadows KP, Tyring SK, Pavia AT, Rallis TM. Resolution of recalcitrant molluscum contagiosum virus lesions in human immunodeficiency virus-infected patients treated with cidofovir. Arch Dermatol. 1997;133:987-90.